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doi: 10.1038/s41392-021-00678-1 369 WangC.AcostaD.McNuttM.BianJ.MaA.FuH.et al

Nat Cell Biol 22(4):476486

The MGF E-peptide is distinct from the mature IGF-1 domain and appears to signal through a mechanism independent of the IGF-1 receptor

This increase in visceral abdominal fat is linked with increased inflammation and free fatty acids that impair metabolic function, and is also linked to a higher risk of cardiovascular disease and metabolic syndrome